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ENDOCET is a painkiller belonging to the class of drugs known as opioids. It relieves pain by acting on specific nerve cells of the spinal cord and brain. Acetaminophen belongs to the group of medications called analgesics (pain relievers) and antipyretics (fever reducers). Oxycodone belongs to the group of medications called narcotic analgesics.
Medicinal ingredients: oxycodone and acetaminophen Non-medicinal ingredients: Corn starch, microcrystalline cellulose, povidone,pregelatinized starch, silicon dioxide, and stearic acid.
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Dosage and Administration
Be sure to follow your doctor’s dosing instructions exactly. Do not increase or decrease your dose without consulting your doctor.
Usual Adult Starting Dose:
The dosage varies according to each individual and can be affected by the severity of the pain as well as each person’s response to the medication.The usual recommended adult dose of ENDOCET (each tablet contains 5 mg oxycodone and 325 mg acetaminophen) is one tablet every 6 hours as needed for pain. ENDOCET is not recommended for people under 18 years of age.
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- ENDOCET tablets should not be administered to patients with known hypersensitivity to oxycodone, acetaminophen, or any other component of this product.
- Oxycodone is contraindicated in any situation where opioids are contraindicated including patients with significant respiratory depression (in unmonitored settings or the absence of resuscitative equipment) and patients with acute or severe bronchial asthma or hypercarbia..
- Patients with severe hepatic insufficiency or active liver disease.
- In patients with known or suspected mechanical gastrointestinal obstruction (e.g., bowel obstruction or strictures) or any diseases/conditions that affect bowel transit (e.g., ileus of any type).
- Patients with suspected surgical abdomen (e.g., acute appendicitis or pancreatitis).
- Patients with mild pain that can be managed with other pain medications.
- Patients with acute or severe bronchial asthma, chronic obstructive airway, or status asthmaticus.
- Patients with acute respiratory depression, elevated carbon dioxide levels in the blood and cor pulmonale.
- Patients with acute alcoholism, delirium tremens, and convulsive disorders.
- Patients with severe CNS depression, increased cerebrospinal or intracranial pressure, and head injury.
- Patients taking monoamine oxidase (MAO) inhibitors (or within 14 days of such therapy).
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Patients should be instructed not to give ENDOCET (oxycodone hydrochloride and acetaminophen) tablets to anyone other than the patient for whom it was prescribed, as such inappropriate use may have severe medical consequences, including death.ENDOCET should be stored securely to avoid theft or misuse.ENDOCET should only be prescribed by persons knowledgeable in the continuous administration of potent opioids, in the management of patients receiving potent opioids for the treatment of pain, and in the detection and management of respiratory depression,including the use of opioid antagonists.Patients should be cautioned not to consume alcohol while taking ENDOCET as it may increase the chance of experiencing serious adverse events, including death.Hyperalgesia that will not respond to a further dose increase of ENCOCET (oxycodone hydrochloride and acetaminophen) can occur at particularly high doses. An ENDOCET(oxycodone hydrochloride and acetaminophen) dose reduction or change in opioid may be required.
Because headache often involves a significant psychological component, an opioid analgesic should only be employed for the treatment of headache when no other treatment is effective, in order to minimize the risk of psychological and physical dependence.
Abuse and Misuse
Like all opioids, ENDOCET is a potential drug of abuse and misuse, which can lead to overdose and death. Therefore, ENDOCET should be prescribed and handled with caution.Patients should be assessed for their clinical risks for opioid abuse or addiction prior to being prescribed opioids. All patients receiving opioids should be routinely monitored for signs of misuse and abuse.
Opioids, such as ENDOCET, should be used with particular care in patients with a history of alcohol and illicit/prescription drug abuse. However, concerns about abuse, addiction, and diversion should not prevent the proper management of pain.ENDOCET is intended for oral use only. The tablets should be swallowed whole, and not chewed or crushed. Abuse of oral dosage forms can be expected to result in serious adverse events, including death. More info